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Hideko Murooka Selected Research

N- (4- ((6,7- dimethoxy- 4- quinolyl)oxy)- 2- methoxyphenyl)- N'- (1- (1,3- thiazole- 2- yl)ethyl)urea

3/2008The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis.
1/2008The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model.
11/2006A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.

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Hideko Murooka Research Topics

Disease

2Melanoma (Melanoma, Malignant)
11/2006 - 03/2005
2Neoplasms (Cancer)
11/2006 - 03/2005
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
03/2008
1Multiple Sclerosis
03/2008
1Disease Progression
01/2008
1Arthritis (Polyarthritis)
01/2008
1Experimental Arthritis
01/2008
1Bone Diseases (Bone Disease)
11/2006
1Bone Resorption
11/2006
1Neoplasm Metastasis (Metastasis)
11/2006
1Osteolysis
11/2006
1Glioma (Gliomas)
03/2005
1Carcinoma (Carcinomatosis)
03/2005
1Body Weight (Weight, Body)
03/2005

Drug/Important Bio-Agent (IBA)

3N- (4- ((6,7- dimethoxy- 4- quinolyl)oxy)- 2- methoxyphenyl)- N'- (1- (1,3- thiazole- 2- yl)ethyl)ureaIBA
03/2008 - 11/2006
3Macrophage Colony-Stimulating Factor Receptor (Receptor, Macrophage Colony Stimulating Factor)IBA
03/2008 - 11/2006
3Tyrosine Kinase InhibitorsIBA
03/2008 - 11/2006
1Myelin-Oligodendrocyte GlycoproteinIBA
03/2008
1AntigensIBA
03/2008
1Collagen Type II (Type II Collagen)IBA
01/2008
1ThiazolesIBA
01/2008
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2008
1Urea (Carbamide)FDA LinkGeneric
01/2008
1LigandsIBA
11/2006
1Macrophage Colony-Stimulating FactorIBA
11/2006
1LC 6IBA
03/2005

Therapy/Procedure

3Oral Administration
01/2008 - 03/2005